Your Treatment Doesnt Accomplish Your Goals
According to the National Psoriasis Foundation, you can expect to be able to develop a treatment program that clears your skin, has few side effects, and complements your lifestyle even with moderate to severe psoriasis.
A study published in Dermatologic Study in 2015 points out that historically this expectation wasnt always realistic.
Before the development of biologics, people with psoriasis were expected to tolerate some degree of skin issues and a wide variety of side effects from medication.
With the wide range of treatment options now available, you can work to successfully manage your condition.
You can work with your healthcare provider to tailor the effectiveness, side effects, and lifestyle requirements of various treatments to develop a program that meets your personal treatment goals.
This may involve switching treatments multiple times until you find one that works for you.
Treatment For Eczema And Psoriasis
Despite the difference in causes, eczema and psoriasis are typically treated similarly. Treatment may include:
- Topical steroids
- Medications and biologicsto suppress the immune system
- Topical antibiotics
- Ultraviolet light therapy
With the right diagnosis and management, you can take back control and get relief from eczema and psoriasis symptoms. To learn more, book an appointment online or over the phone with Riviera Allergy Medical Center today.
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What Do Psoriasis And Eczema Look Like
Signs and symptoms of psoriasis
The most common type of psoriasis is plaque psoriasis. Plaque psoriasis appears as thick, raised, red patches on the skin that are covered with white scales made of old, dead skin cells. These plaques can be itchy and painful. They can also crack and bleed.
Psoriasis can affect any part of the skin, but it usually shows up on the knees, elbows, scalp, and lower back. Other forms of psoriasis can occur on the genitals or in your skin folds, like in your armpits . Psoriasis can also just involve the hands and feet .
Up to 35% of people with psoriasis also have nail changes related to psoriasis. This includes:
Small pits or holes in the nail
Yellow or brown nail color
Thickening of the nail
Changes to the nail shape
There are several other serious health problems that can be more likely if you have psoriasis. Some of the more common issues include:
Signs and symptoms of eczema
Eczema appears as red, dry patches of skin that are very itchy. Some people with eczema scratch these areas a lot, which can lead to bleeding and thick or leathery skin. Unlike psoriasis, eczema can become infected with bacteria or viruses.
Although eczema can affect any part of the skin, some areas are more common. In infants, eczema usually happens on the cheeks, elbows, and knees. In older children and adults, eczema usually affects the insides of the elbows, behind the knees, and the hands and wrists.
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Morphosys And Galapagos Announce Positive Phase I Results For Atopic Dermatitis Treatment
Phase I results show promise for a new treatment for atopic dermatitis that may become a strong competitor to the market leader, Humira.
Morphosys and Galapagos are developing an antibody that could compete with the worlds best selling drug, Humira. The team announced details on positive results of a Phase I trial for treating atopic dermatitis at the American Academy of Dermatology Meeting in San Diego. Initial results were reported in September 2017. The Phase I study tested the action of MOR106, an IL-17C antibody, in patients with AD. Overall, the outcome indicated MOR106 was well tolerated by patients and showed initial signs of activity.
Atopic dermatitis is the most severe and common form of skin eczema that causes dry skin, rashes and itching on a patients face, inner side of the elbows and knees, and on their hands and feet. AbbVies Humira, an anti-TNF monoclonal antibody used to treat a range of conditions including atopic dermatitis, rheumatoid arthritis, and irritable bowel disease, is the current market leader for atopic dermatitis treatments. This has led the drug to top the best-selling lists for years, with $16Bn in sales in 2017 alone.
A drug for atopic dermatitis would especially benefit certain regions of Europe given that its occurrence is connected to age and climate. For example, 25% of the Northern European population is affected, where there is less sunlight, while only 1% of the coastal Southern European population is affected.
Treatments To Help People With Severe Eczema
Eczema symptoms and effective therapies vary. Treatment for severe eczema may include at-home treatments plus prescription medications to ease the awful, stinging itch and discomfort.
Researchers are conducting clinical trials on new medications in the hopes of finding long-term solutions for managing eczema. There have been many advancements, with ideally more to come.
Other than regular cleaning and moisturizing, here are suggested treatments for severe eczema.
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Side Effects Requiring Immediate Medical Attention
Along with its needed effects, adalimumab may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking adalimumab:
- lower back or side pain
- muscle aches and pains
- pain or tenderness around the eyes or cheekbones
- rapid and sometimes shallow breathing
- red, scaling, or crusted skin
- sudden numbness and weakness in the arms and legs
- unusual bleeding or bruising
What Innovative Treatments Do You Offer For Eczema And Psoriasis
Correct diagnosis is the first step. We take a thorough patient history and perform detailed testing to determine the skin condition. Depending on your history and symptoms, we may ask for tests such as a biopsy, patch tests or other diagnostic studies. Once we are sure of the diagnosis, we will make treatment recommendations.
We offer a wide range of extensive topical and systemic therapies, as well as ultraviolet light therapycalled phototherapy. UV therapy given in a controlled medical setting can be extremely effective treatments for both conditions depending on the patient.
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Difference #: Location Of Symptoms
Generally speaking, both conditions can appear on most parts of the body. However, there are certain areas where youÃ¢re more prone to see psoriasis and certain areas youÃ¢re more likely to see eczema developing.
Eczema tends to develop Ã¢ on the parts of the body where there are creases. For instance, on your inner elbow or behind your knees. It can also form on your neck, wrists and ankles.
Psoriasis tends to develop Ã¢ on your elbows, knees, scalp and face, lower back, palms of your hands, soles of your feet, mouth and lips, ears, eyelids, fingernails and toenails.4
- Avoiding extremely hot temperatures Ã¢ particularly hot baths or showers
- Moisturising the skin
Diet can also potentially play a part in both conditions, seeing as theyÃ¢re both inflammatory skin conditions. Eating certain anti-inflammatory food, such as these, can potentially help calm the skin:
- Fruit and vegetables â especially berries, cherries and leafy greens
- Oily fish â salmon, sardines, and other fish rich in Omega 3 fatty acids
- Antioxidant-rich herbs and spices Ã¢ such as thyme, sage, cumin and ginger
- Healthy sources of fat Ã¢ such as olive oil, seeds, and nuts
We hope that by reading this psoriasis vs eczema article, youÃ¢re now a bit clearer on the difference between eczema and psoriasis? While there are parallels between the two, there are also lots of differentiators that are possible to identify the first step is knowing that they exist.
23 July 2020
Relationship Between Biosimilars And Biologics
Biosimilars are highly similar to their biologic reference product. All biologics, including biosimilars:
- Target specific parts of the immune system rather than impacting the entire immune system
- Are given as an injection or IV infusion
To be approved as a biosimilar for a particular reference biologic, the biosimilar must be:
- Highly similar to the reference product and cannot have any clinically meaningful differences in terms of safety or efficacy
- Approved for the indication and condition for which the reference product is approved
- Be given the same form and in the same dosage as the reference product
- The same mechanism of action as the reference product, which means it works the same way in the body
An interchangeable biosimilar must meet the biosimilar standard plus an additional standard that the treatment will produce the same clinical result as the reference product in any given patient. If a biosimilar is approved as interchangeable, a pharmacist may substitute it without letting your prescribing health care provider know, in some states.
Keep in mind that biosimilars are not exact copies of their biologic reference product. Biologics are large and complex molecules from living sources that cannot be exactly copied.
Many considerations go into a treatment decision. Always speak with your health care provider about the potential risks and benefits of a treatment recommendation.
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Humira For Psoriatic Arthritis
Humira is FDA-approved to treat psoriatic arthritis thats active in adults. Active means that you have symptoms. The goal of Humira is to reduce the signs and symptoms of PsA, help prevent the condition from getting worse, and improve mobility.
PsA is a type of arthritis that can occur in people with psoriasis. PsA results in red, scaly patches on the skin and scalp, plus classic arthritis symptoms of swollen, sore joints. With PsA, there are often periods of flare-ups, in which symptoms occur or get worse, and periods of remission, times when symptoms disappear.
PsA occurs when your immune system mistakenly attacks your joints and skin. Humira treats PsA by blocking a protein called TNF. This decreases the activity of your immune system, leading to a reduction in the number and severity of PsA symptoms.
Effectiveness for psoriatic arthritis
Humira has shown to be effective in treating moderate to severe PsA in adults.
In clinical studies, researchers compared Humira with a placebo to see if Humira was better at reducing the severity of PsA.
In one study, 20% of people who took Humira had a 70% reduction in the severity and number of PsA symptoms after 12 weeks. This was compared with just 1% of people who took a placebo. After 24 weeks, 23% of people who took Humira 70% reduction in PsA symptoms compared with 1% of people who took placebo.
Fingernail Psoriasis Study Design12913
A Phase 3, randomized, double-blind study evaluated adult subjects with moderate to severe fingernail psoriasis who also had moderate to severe chronic plaque psoriasis.1,2
BSA=body surface area EOW=every other week mNAPSI=modified Nail Psoriasis Severity Index
PGA-F=Physicians Global Assessment of Fingernail Psoriasis PGA-S=Physicians Global Assessment of Skin Psoriasis.
Key inclusion criteria were adult subjects with2:
- Moderate to severe chronic plaque psoriasis with disease duration of at least 6 months and psoriasis in at least one fingernail
- Fingernail involvement moderate as measured by 5-point PGA-F scale
- mNAPSI score of target fingernail 8
- BSA 10%, or 5% BSA with a total mNAPSI score for all fingernails 20
Primary endpoint was proportion of subjects achieving PGA-F of 0 or 1 and at least 2-grade improvement from baseline at Week 26.
Key secondary endpoint was proportion of subjects achieving 75% improvement from baseline in mNAPSI at Week 26.
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Humira For Other Conditions
In addition to the uses listed above, Humira may be used off-label. Off-label drug use is when a drug thats approved for one use is used for a different one thats not approved. And you may wonder if Humira is used for certain other conditions. Below is information on other possible uses for Humira.
Humira for osteoarthritis
Humira isnt approved by the FDA for treating osteoarthritis, a type of arthritis. But the drug may be used off-label for the condition.
One study looked at 56 people with moderate to severe osteoarthritis of the knee. They were given an injection of either Humira or hyaluronic acid directly in their knee. Researchers found that people who received Humira reported more significant decreases in pain compared with people who received hyaluronic acid.
If youd like to learn more about using Humira for osteoarthritis, talk with your doctor. They can recommend the best treatments for you.
Humira for sarcoidosis
Humira isnt FDA-approved to treat sarcoidosis. But the drug may be used off-label for the condition.
A systematic review looked at studies of TNF blocker drugs for treating different types of sarcoidosis. The review found that Humira may work to treat forms of sarcoidosis that affect the skin or eyes.
Humira for IBS
Humira isnt FDA-approved to treat IBS.
Humira for lupus
Humira For Ulcerative Colitis
Humira is FDA-approved to treat moderate to severe ulcerative colitis in adults thats active. Active means that you have symptoms. You mustve already tried drugs called immunosuppressants, but they didnt work for you. Examples of these immunosuppressants include 6-mercaptopurine , azathioprine, and corticosteroids.
Humira wasnt studied in people with UC who had previously used other TNF blocker drugs.
The goal of Humira is to help you reach remission, which is a time when your symptoms ease, become less frequent, or disappear.
The inflammation results in tiny sores, called ulcers, throughout the lining of your colon. This causes your bowels to move their contents rapidly and empty frequently. As a result, you may have symptoms such as diarrhea, belly pain, malnutrition , weight loss, and bloody stools.
Its thought that UC results from an overactive immune system. Humira treats UC by blocking a protein called TNF. This decreases the activity of your immune system, leading to a reduction in the number and severity of colon ulcers.
Effectiveness for ulcerative colitis
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Can Biosimilars Be Used With Other Treatments
It is important to tell your health care provider about all treatments, medicines, vitamins or supplements that you are taking.
Like all biologics, biosimilars can be used with other treatment options including topicals and phototherapy. The biologics Enbrel, Humira and Remicade are shown to be safe and effective when taken with methotrexate. This means that their biosimilars, including Erelzi, Amjevita, and Inflectra, may be safe and effective when taken with methotrexate.
- With Inflectra being the biosimilar to Remicade, its use in combination with phototherapy may increase the risk for skin cancer.
- No drugs that interact with biologics should be combined with their respective biosimilars.
How Should I Use This Medication
This medication is given by subcutaneous injection, usually in the front of the thigh or abdomen. The dose depends on the condition being treated.
For rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis, the recommended dose for adults is 40 mg every other week.
For adults with Crohn’s disease or ulcerative colitis, the recommended dose is a first dose of 160 mg, then 80 mg 2 weeks after the first dose, then 40 mg every second week starting 4 weeks after the first dose.
For adults with psoriasis or uveitis, the recommended dose is a first dose of 80 mg, then 40 mg every other week starting one week after the first dose.
For children over 2 years old with uveitis, the dose of adalimumab is 20 mg every other week for children who weigh less than 30 kg and 40 mg every other week for children who weigh 30 kg or more. Your doctor may suggest a higher starting dose for children 6 years of age or older.
When treating polyarticular juvenile idiopathic arthritis for children over 2 years old, the dose of adalimumab is 20 mg every other week for children who weigh 10 kg to less than 30 kg. For children who weigh 30 kg or more, the dose is 40 mg given every other week.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are using the medication without consulting your doctor.
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Humira For Rheumatoid Arthritis
Humira is FDA-approved to treat moderate to severe rheumatoid arthritis thats active in adults. Active means that you have symptoms. The goal of Humira is to significantly ease signs and symptoms of RA and help limit joint damage and improve mobility.
RA is a chronic autoimmune disease that causes joint pain and inflammation throughout your body. Autoimmune means that your immune system mistakenly attacks your body. With RA, there are often periods of flare-ups, in which symptoms occur or get worse, and periods of remission, times when symptoms disappear.
Humira treats RA by blocking a protein called TNF. This decreases the activity of your immune system, leading to a reduction in the number and severity of RA symptoms.
Effectiveness for rheumatoid arthritis
Humira has been proven effective for treating RA in adults.
Clinical studies of people with RA compared Humira with a placebo. In some studies, people also took methotrexate with either Humira or a placebo. Researchers wanted to see how effective Humira was at helping people achieve a 20%, 50%, or 70% reduction in the severity and number RA symptoms. Across these studies, researchers found that Humira was more effective than the placebo.
In two studies, 12% to 21% of people who took Humira by itself or with methotrexate had a 70% reduction in the severity and number of RA symptoms after 6 months. This was compared with just 2% to 3% of people who took a placebo by itself or with methotrexate.